Uridine-5'-(γ-thio)-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 6 months after date of delivery
Molecular Formula: C9H15N2O14P3S (free acid)
Molecular Weight: 500.20 g/mol (free acid)
Purity: ≥ 85 % (HPLC), contains approx. 10 % UDP, which UTPγS decomposes to at room temperature
Spectroscopic Properties: λmax 262 nm, ε 10.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Ligand for purinergic receptors:
Enzymatic stable and potent agonist at P2Y2/P2Y4
[1,2,3,4] and P2Y6receptors
Please note: For reasons of stability, please make sure that the pH value of a solution of this product never drops below 7.0. This can be achieved by dissolving the nucleotide in a buffer of your choice (50 - 100 mM, pH 7 - 10). Dissolve and adjust concentration photometrically.
 Higgins et al. (2014) Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes. Mediators Inflamm. 293925.
 Zizzo M. et al. (2012) Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. Purinergic Signal. 8 (2):275.
 De Proost et al. (2009) Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. The FASEB Journal 23 (4):1153.
 Chopra et al. (2008) Expression and function of rat urothelial P2Y receptors. Am J Physiol Renal Physiol 294:F821.
 Malmsjö et al. (2003) The stable pyrimidines UDPβS and UTPγS discriminate between contractile cerebrovascular P2 receptors. Eur. J. Pharmacol. 458 (3):305.
Seifert et al. (2012) Inhibitors of membranous adenylyl cyclases. Trends Pharmacol. Sci. 33 (2):64.
Sugihara M. et al. (2011) Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat. J. Pharmacol Sci. 115 (3):293.
Stroupe et al. (2009) Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components. PNAS 106 (42):17626.
Read et al. (2005) UTP-dependent turnover of Trypanosoma brucei mitochondrial mRNA requires UTP polymerization and involves the RET1 TUTase. RNA 11:763.