UTPγS

For general laboratory use.

Shipping: shipped on dry ice

Storage Conditions: store at -20 °C

Shelf Life: 6 months after date of delivery

Molecular Formula: C₉H₁₅N₂O₁₄P₃S (free acid)

Molecular Weight: 500.20 g/mol (free acid)

Exact Mass: 499.95 g/mol (free acid)

CAS#: 79049-97-1

Purity: ≥ 85 % (HPLC), contains approx. 10 % UDP, which UTPγS decomposes to at room temperature

Form: solid

Color: white to off-white

Spectroscopic Properties: λ_max 262 nm, ε 10.0 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Specific Ligands:

Ligand for purinergic receptors:
Enzymatic stable and potent agonist at P2Y₂/P2Y₄
^[1,2,3,4] and P2Y₆^[5]receptors

Please note: For reasons of stability, please make sure that the pH value of a solution of this product never drops below 7.0. This can be achieved by dissolving the nucleotide in a buffer of your choice (50 - 100 mM, pH 7 - 10). Dissolve and adjust concentration photometrically.

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Selected References:
[1] Higgins et al. (2014) Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes. Mediators Inflamm. 293925.
[2] Zizzo M. et al. (2012) Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. Purinergic Signal. 8 (2):275.
[3] De Proost et al. (2009) Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. The FASEB Journal 23 (4):1153.
[4] Chopra et al. (2008) Expression and function of rat urothelial P2Y receptors. Am J Physiol Renal Physiol 294:F821.
[5] Malmsjö et al. (2003) The stable pyrimidines UDPβS and UTPγS discriminate between contractile cerebrovascular P2 receptors. Eur. J. Pharmacol. 458 (3):305.
Seifert et al. (2012) Inhibitors of membranous adenylyl cyclases. Trends Pharmacol. Sci. 33 (2):64.
Sugihara M. et al. (2011) Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat. J. Pharmacol Sci. 115 (3):293.
Stroupe et al. (2009) Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components. PNAS 106 (42):17626.
Read et al. (2005) UTP-dependent turnover of Trypanosoma brucei mitochondrial mRNA requires UTP polymerization and involves the RET1 TUTase. RNA 11:763.