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AMP-α-F

(ApF)

Adenosine-5'-(α-fluoro)-monophosphate, Sodium salt

Adenosine-5'-(1-fluoro)-monophosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-943-5 5 mg 105,08 Add to Basket/Quote Add to Notepad
NU-943-25 25 mg 420,31 Add to Basket/Quote Add to Notepad
Structural formula of AMP-α-F ((ApF), Adenosine-5'-(α-fluoro)-monophosphate, Sodium salt)
Structural formula of AMP-α-F

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C10H13FN5O6P (free acid)

Molecular Weight: 349.21 g/mol (free acid)

CAS#: 19375-33-8 (free acid), 15503-75-0 (sodium salt)

Purity: ≥ 95 % (HPLC)

Form: solid

Spectroscopic Properties: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Substrate for snake venom phosphodiesterase [1,2]
Substrate for Fhit proteins [3]
Inhibitor of adenlyate kinase [4]

Selected References:
[1] Baranowski et al. (2016) A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I. Org. Biomol. Chem. 14 (20):4595.
[2] Baranowski et al. (2015) Synthesis of fluorophosphate nucleotide analogues and their characterization as tools for ¹⁹F NMR studies. J. Org. Chem. 80 (8):3982.
[3] Guranowski et al. (2008) Fhit proteins can also recognize substrates other than dinucleoside polyphosphates. FEBS Lett. 582 (20):3152.
[4] Scoblov et al. (1996) Modified nucleotides as substrates and inhibitors of adenylate kinase from different sources. FEBS Lett. 395 (2-3):283.