6-Mercaptopurine-riboside-5'-monophosphate, Sodium salt
For research use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H13N4O7PS (free acid)
Molecular Weight: 364.26 g/mol (free acid)
Exact Mass: 364.02 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 322 nm, ε 27.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Neurath et al. (2005) 6-Thioguanosine Diphosphate and Triphosphate Levels in Red Blood Cells and Response to Azathioprine Therapy in Crohns Disease. Clinical Gastroenterology and Hepatology 3 (10): 1007.
Wielinga et al. (2002)Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol. 62 (6):1321.
Szabados et al. (1994) 5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRFCEM leukemia cells: purification, pH dependence, and inhibitors. Biochemistry 33 (47):14237.
Stet et al. (1993) A biochemical basis for synergism of 6-mercaptopurine and mycophenolic acid in Molt F4, a human malignant T-lymphoblastic cell line. Biochim Biophys Acta. 1180 (3):277.
Drake et al. (1982) Metabolism and mechanisms of action of 9- (tetrahydro-2-furyl)-6-mercaptopurine in Chinese hamster ovary cells. Chem Biol Interact. 41 (1):105.