HTLV-1 Mosaic (residues 374-400/190-207)

For general laboratory use.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Purity: > 95 % (SDS-PAGE)

Form: liquid (Supplied in 20 mM Phosphate buffer pH 7.5)

Applications:
Antigen in ELISA and Western blots, excellent antigen for early detection of HTLV infections, with minimal specificity problems.

Description:
The protein contains the HTLV-1 gp21/gp46 immunodominant fragments, amino acids: 374-400 (gp21) and 190-207 (gp46). The protein is purified by proprietary chromatographic technique.

Background: Human T-cell leukemia virus (HTLV)-1 and -2 are deltaretroviruses that infect a wide range of cells. HTLV-1 has been found primarily in CD4⁺ and CD8⁺ T-lymphocytes in vivo, whereas CD8⁺ T-lymphocytes are thought to be the in vivo reservoir of HTLV-2.

Specificity: Immuno reactive with all sera of HIV-I infected individuals.

BIOZ Product Citations:

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Selected References:
Toedter et al. (1991) Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infection. AIDS. Res. Hum. Retroviruses. 8:527.
Segal-Eiras et al. (1991) HTLV-I p24 antigen in circulating immune complexes associated with acute Tlymphoblastic leukemia. Haematologica. 76:441.
Stransky et al. (1991) Ultrastructural localization of HTLV-I gag proteins p19 and p24 by single and double immunogold labeling. J. Histochem. Cytochem. 39:185.
Ando et al. (1990) p24 protein of a human T-lymphotropic virus type-I (HTLV-I) producing cell line (TCL-Kan) reacts with some normal pregnant women's sera. Nippon. Sanka. Fujinka. Gakkai. Zasshi. 42:1251.
Ziegler et al. (1989) Immunohistochemical localization of HTLV-I p19- and p24-related antigens in synovial joints of patients with rheumatoid arthritis. Am. J. Pathol. 135:1.
Grimaldi et al. (1988) HTLV-I-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-I p24 antibody. Ann. Neurol. 24:727.