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HIV-type O Envelope

Human Immunodeficiency Virus Type O Antigen

recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-1209 100 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Purity: > 95 % (SDS-PAGE, RP-HPLC)

Form: liquid (Supplied in 20 mM PBS pH 7.8, 0.5 M NaCl, 1 mM DTT, 8 M urea and 0.4 M imidazole)

pH: 7.8

Description:
Recombinant HIV type-O peptide, containing the HIV type-O transmembrane envelopederived specific sequence. Detects all clades of HIV type-O infected individuals responding to HIV type-O envelope proteins. The protein was purified by proprietary chromatographic technique.

Background: HIV belongs to the retrovirus family, distinguished by possession of a viral reverse transcriptase that transcribes viral RNA into DNA which is integrated into the host-cell genome. Based on genetic variability in the envelope (env) gene, HIV-1 can be subdivided into at least 10 distinct subtypes (designated A to J) responsible for separate geographic pandemics. Phylogenetic analyses have shown that each subtype in this major group (group M) is approximately equidistant from the others, as if arising from a common ancestor. In contrast, a few divergent HIV-1 strains form a cluster distinct from group M and have been categorized as members of the outlier group (group O).

Applications:
May be used in ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.

Specificity: Immuno reactive with all sera of HIV type-O infected individuals.

Selected References:
Payan et al. (2003) [Measuring the HIV viral load with LCx (Abbott): importance for the therapeutic follow-up of 3 patients infected by type O HIV]. Transfus. Clin. Biol. 10:72.
Miguel et al. (1998) Analysis of pol Gene Heterogeneity, Viral Quasispecies, and Drug Resistance in Individuals Infected with Group O Strains of Human Immunodeficiency Virus Type 1. J. Virol. 72:9002.