HIV-type O Envelope

For general laboratory use.

Please centrifuge briefly before opening (volume ≤2 ml).

Shipping: shipped at 4 °C

Storage Conditions: store at 4 °C
Please do NOT freeze

Shelf Life: 12 months

Purity: > 95 % (SDS-PAGE, RP-HPLC)

Form: liquid in Water

Applications:
May be used in ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.

Description:
Recombinant HIV type-O peptide, containing the HIV type-O transmembrane envelopederived specific sequence. Detects all clades of HIV type-O infected individuals responding to HIV type-O envelope proteins. The protein was purified by proprietary chromatographic technique.

Background: HIV belongs to the retrovirus family, distinguished by possession of a viral reverse transcriptase that transcribes viral RNA into DNA which is integrated into the host-cell genome. Based on genetic variability in the envelope (env) gene, HIV-1 can be subdivided into at least 10 distinct subtypes (designated A to J) responsible for separate geographic pandemics. Phylogenetic analyses have shown that each subtype in this major group (group M) is approximately equidistant from the others, as if arising from a common ancestor. In contrast, a few divergent HIV-1 strains form a cluster distinct from group M and have been categorized as members of the outlier group (group O).

Specificity: Immuno reactive with all sera of HIV type-O infected individuals.

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Selected References:
Payan et al. (2003) [Measuring the HIV viral load with LCx (Abbott): importance for the therapeutic follow-up of 3 patients infected by type O HIV]. Transfus. Clin. Biol. 10:72.
Miguel et al. (1998) Analysis of pol Gene Heterogeneity, Viral Quasispecies, and Drug Resistance in Individuals Infected with Group O Strains of Human Immunodeficiency Virus Type 1. J. Virol. 72:9002.