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Ran - T24N

Ras-related nuclear protein, TC4

human, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-212 50 μg 271,40 Add to Basket/Quote Add to Notepad

For general laboratory use.

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 24.0 kDa (216 amino acids)

Accession number: NM_006325

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 20 mM KH2PO4/K2HPO4 pH 7.0, 6.5 mM DTE, 150 mM KCl, 5 mM MgCl2 and 10% glycerol)

Ran (Ras-related nuclear protein, TC4) belongs to the superfamily of GTP binding proteins. It acts in cellular processes such as nuclear transport, mitotic spindle assembly, and post-mitotic nuclear assembly. The mutation T24N results in no or little binding to GTP and is known to act as a negative inhibitor of nuclear import. Protein preparation is 18% GDP-loaded, measured by HPLC.

BIOZ Product Citations:

Selected References:
Dasso (2002) The Ran GTPase: Theme and Variations. Current Biology 12:502.
Renault et al. (2001) Structural Basis for Guanine Nucleotide Exchange on Ran by the regulator of Chromosome Condensation (RCC1). Cell 105:245.
Sekimoto et al. (1996) Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4 J. Biol. Chem. 271:31017.