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Rab4BGST-His

Ras-associated, small GTP-binding protein

human, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-183 50 μg 212,18 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Accession number: NM_004578

Accession number: NM_004578

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM mercaptoethanol)

Activity: 100 pmol of protein can bind > 80 pmol of GDP.

Description:
Rab4B is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. Rab4 is associated with early endosomes and regulates recycling vesicle formation. Together with Rab5 it acts to control influx and efflux out of early endosomes. The GST-Tag facilitates the protein`s application in typical GST pull-down assays.

Selected References:
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071.
Mohrmann et al. (2002) Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle. J. Biol. Chem. 277:32029.
Somsel et al. (2000) Rab GTPases coordinate endocytosis. J. Cell Sci. 113:183.
Chamberlain et al. (2004) The p85alpha Subunit of Phosphatidylinositol 3’-Kinase Binds to and Stimulates the GTPase Activity of Rab Proteins. J. Biol. Chem. 279 (47):48607.