NPE-caged-AppNHp

For general laboratory use.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
store dark
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 6 months after date of delivery

Molecular Formula: C₁₈H₂₄N₇O₁₄P₃ (free acid)

Molecular Weight: 655.35 g/mol (free acid)

Exact Mass: 655.06 g/mol (free acid)

CAS#: 116271-21-7

Purity: ≥ 95 % (HPLC)

Form: solution in water

Color: colorless to slightly yellow

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λ_max 260 nm, ε 18.0 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Applications:
Agonistic ligand, mainly for nucleoside receptor A₁
Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors. The caged form is protected during uptake and transport in animal experiments and can be well-directed released through activation at the target tissue.

BIOZ Product Citations:

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Selected References:
Volonte et al. (2009) Membrane components and purinergic signalling: the purinome, a complex interplay among ligands, degrading enzymes, receptors and transporters. FEBS J. 276:318.
Yegutkin (2008) Nucleotide and nucleoside converting enzymes: Important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 1783:673.
Williams et al. (1986) Effects of purine nucleotides on the binding of [3H]cyclopentyladenosine to adenosine A1-receptors in rat brain membranes. J. Neurochem. 47 (1):88.