2'-Deoxyuridine-5'-[(α,β)-imido]diphosphate, Sodium salt
For research use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H15N3O10P2 (free acid)
Molecular Weight: 387.17 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 262 nm, ε 10.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)
BIOZ Product Citations:
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Kovári et al. (2008) Methylene substitution at the ab bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. J. Biol. Chem. 71:308.
Barabás et al. (2004) Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase. J. Biol. Chem. 279 (41):42907.
Persson et al. (1996) Synthesis of 2'-deoxyuridine 5'- (alpha,beta-imido)triphosphate: A substrate analogue and potent inhibitor of dUTPase. Bioorgan. Med. Chem. 4 (4):553.