Research on bacterial second messengers has recently experienced tremendous progress, and cyclic di-AMP (c-di-AMP) is one of the rising stars. c-di-AMP is essential for the growth of several human bacterial pathogens - e.g. Staphylococcus aureus or Borrelia burgdorferi - by regulating DNA damage repair, potassium homeostasis, cell wall and membrane synthesis and sporulation. To solve the numerous riddles relating to c-di-AMP metabolism and function (Scheme 1), synthetic c-di-AMP serves as:
c-di-AMP is now available from Jena Bioscience. For other cyclic or linear dinucleotide pairs, please inquire!
|Compound||Cat. No.||Amount||Price (€)|
|NU-954L||5 x 1 μmol||380,00|
Scheme 1: The c-di-AMP signaling network. Biosynthesis and degradation of c-di-AMP are triggered by external stimuli that modulate the activities of diadenylate cyclases (DACs) and phosphodiesterases (PDEs) in a widely elusive manner. DACs catalyze the cyclization of two ATP molecules, yielding c-di-AMP that acts as a ligand of transcription factors, potassium transporters, protein kinases and RNA riboswitches. However, most regulatory effects of c-di-AMP-binding are poorly understood and subject to current investigations. In the PDE-catalyzed clearance reaction, c-di-AMP is hydrolyzed to 5'-pApA or AMP.
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