Viral proteins are often difficult to express in bacterial expression systems due to misfolding or missing glycosylation. The eukaryotic expression system LEXSY is especially well-suited for the expression of viral proteins with correct folding and antigen activity (see Figure 1 and Table 1).
| Viral protein | References |
|---|---|
| Hepatitis C core protein | Bolhassani et al., 2017[1] |
| Hepatitis C E1E2 complex | Grzyb et al., 2016[2] |
| Hepatitis C sHBsAg protein | Czarnota et al., 2016[3] |
| Hendra attachment protein | Fischer et al., 2016[4] |
| Hepatitis E capsid protein | Baechlein et al., 2013[5] |
Need further information? Please check out the LEXSY section or contact Andreas by email at expression@jenabioscience.com!
[1] Bolhassani et al. (2017) Comparison of HCV Core and CoreE1E2 Virus-Like Particles Generated by Stably Transfected Leishmania tarentolae for the Stimulation of Th1 Immune Responses in Mice. Curr. Drug Deliv. 14:1040.
[2] Grzyb et al. (2016) Immunogenicity and functional characterization of Leishmania-derived hepatitis C virus envelope glycoprotein complex. Sci. Rep. 6:30627.
[3] Czarnota et al. (2016) Immunogenicity of Leishmania-derived hepatitis B small surface antigen particles exposing highly conserved E2 epitope of hepatitis C virus. Microb. Cell Fact. 15:62.
[4] Fischer et al. (2016) Expression, characterisation and antigenicity of a truncated Hendra virus attachment protein expressed in the protozoan host Leishmania tarentolae. J. Virol. Methods 228:48.
[5] Baechlein et al. (2013) Expression of a truncated hepatitis E virus capsid protein in the protozoan organism Leishmania tarentolae and its application in a serological assay. J. Virol. Methods 193:238.
