» Sign in / Register

Viral proteins expressed in LEXSY

Viral proteins are often difficult to express in bacterial expression systems due to misfolding or missing glycosylation. The eukaryotic expression system LEXSY is especially well-suited for the expression of viral proteins with correct folding and antigen activity (see Figure 1 and Table 1).

Figure 1: LEXSY cells expressing the E1E2 complex of hepatitis C virus envelope proteins (green). From Grzyb et al., 2016[2].

Table 1: Selection of viral proteins expressed with LEXSY.

Viral protein References
Hepatitis C core protein Bolhassani et al., 2017[1]
Hepatitis C E1E2 complex Grzyb et al., 2016[2]
Hepatitis C sHBsAg protein Czarnota et al., 2016[3]
Hendra attachment protein Fischer et al., 2016[4]
Hepatitis E capsid protein Baechlein et al., 2013[5]
Dr. Andreas Licht

Need further information? Please check out the LEXSY section or contact Andreas by email at expression@jenabioscience.com!


[1] Bolhassani et al. (2017) Comparison of HCV Core and CoreE1E2 Virus-Like Particles Generated by Stably Transfected Leishmania tarentolae for the Stimulation of Th1 Immune Responses in Mice. Curr. Drug Deliv. 14:1040.
[2] Grzyb et al. (2016) Immunogenicity and functional characterization of Leishmania-derived hepatitis C virus envelope glycoprotein complex. Sci. Rep. 6:30627.
[3] Czarnota et al. (2016) Immunogenicity of Leishmania-derived hepatitis B small surface antigen particles exposing highly conserved E2 epitope of hepatitis C virus. Microb. Cell Fact. 15:62.
[4] Fischer et al. (2016) Expression, characterisation and antigenicity of a truncated Hendra virus attachment protein expressed in the protozoan host Leishmania tarentolae. J. Virol. Methods 228:48.
[5] Baechlein et al. (2013) Expression of a truncated hepatitis E virus capsid protein in the protozoan organism Leishmania tarentolae and its application in a serological assay. J. Virol. Methods 193:238.