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HBV-Core (residues 1-186)

Hepatitis B Virus Core Protein

recombinant, E. coli

Product Cat. No. Amount Price (EUR) Buy / Note
HBV-Core (residues 1-186) PR-1122 100 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 25 mM Tris-HCl pH 8.0, 1.5 mM urea and 50% glycerol)

pH: 8.0

Description:
Hepatitis B Virus Core Antigen contains the fragment of core protein immunodominant regions, amino acids: 1-186 fused to a His-tag. HBV core proteins are purified by proprietary chromatographic techniques.

Background:
Hepatitis B Virus (HBV) is a small enveloped virus that belongs to the hepadnavirus family. The human Hepatitis B Virus (HBV) has a compact genome encoding four major overlapping coding regions: the core, polymerase, surface and X. The core protein is a structural protein. It packages its own mRNA, which is also known as the pregenomic RNA, to form the core particle. The increase of the core RNA expression has been shown to increase the viral replication rate.

Applications:
Immunochromatography (capture and conjugate)
Immunogen for monoclonal antibody production
ELISA

Specificity:
Immunoreactive with sera of HBV-infected individuals.

Selected References:
Le Pogam et al. (2005) Exposure of RNA templates and encapsidation of spliced viral RNA are influenced by the argininerich domain of human hepatitis B virus core antigen (HBcAg 165- 173). J. Virol. 79:1871.
Shi et al. (2004) Therapeutic polypeptides based on HBcAg (18-27) CTL epitope can induce antigen-specific CD (8) (+) CTL-mediated cytotoxicity in HLA-A2 transgenic mice. World J. Gastroenterol. 10:1222.
Szkaradkiewicz et al. (2003) HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B. Virus Res. 97:127.