Epstein-Barr Virus Capsid Antigen
recombinant, E. coli
For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Purity: > 95 % (SDS-PAGE, RP-HPLC)
Form: liquid (Supplied in 25 mM glycine pH 9.6 and 50% glycerol)
Recombinant Epstein-Barr Virus protein contains the EBV (HHV-4) p23 fragment, amino acids 1-162. The protein is purified by proprietary chromatographic technique.
Background: Epstein-Barr virus, frequently referred to as EBV, is a member of the gamma herpesvirus family and one of the most common human viruses. The virus occurs worldwide, and most people become infected with EBV sometime during their lives. It persists in B lymphocytes for the life of the host. EBV p23 is a viral late complex associated with virion particles and consists of two gene products, BFRF3 (p18) and BLRF2 (p23). IgG to the viral capsid antigen appears in the acute phase, peaks at 2 to 4 weeks after onset, declines slightly, and then persists for life.
Antigen in ELISA and Western blots, excellent antigen for detection of HHV-4 (EBV) with minimal specificity problems.
Specificity: Immunoreactive with all sera of EBV infected individuals.
Faerber et al. (2001) Serological diagnosis of Epstein-Barr virus infection by novel ELISAs based on recombinant capsid antigens p23 and p18. J. Med. Virol. 63:271.
Hinderer et al. (1999) Serodiagnosis of Epstein-Barr virus infection by using recombinant viral capsid antigen fragments and autologous gene fusion. J. Clin. Microbiol. 37:3239.