Toxoplasma Gondii Microneme Protein 3
Toxoplasma gondii, recombinant, E. coli
For in vitro use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Purity: > 95 % (SDS-PAGE)
Form: liquid (Supplied in 50 mM Tris-HCl pH 8.0, 1.5 M urea and 0,1 mM EDTA)
Antigen in ELISA and Western blots, excellent antigen for detection of Toxoplasma gondii with minimal specificity problems.
The protein contains the Toxoplasma gondii MIC3 immunodominant regions, amino acids 234-306. The protein is purified by proprietary chromatographic technique.
Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that infects all warmblooded animals, including humans, and causes toxoplasmosis. The homodimeric micronemal protein MIC3, which is a potent adhesin molecule of T. gondii, could be a significant candidate vaccine against toxoplasmosis.
Specificity: Immunoreactive with sera of T. gondii- infected individuals.
BIOZ Product Citations:
Please click the arrow on the right to expand the citation list. Click publication title for the full text.
Ismael et al. (2003) The MIC3 gene of Toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis. Infect. Immun. 71:6222.
Cerede et al. (2002) The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin. EMBO J. 21:2526.
Garcia-Reguet et al. (2000) The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite. Cell. Microbiol. 2:353.