Human T-cell Leukemia Virus Type-1, Envelope mosaic protein
recombinant, E. coli
For in vitro use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Purity: > 95 % (SDS-PAGE)
Form: liquid (Supplied in 20 mM Phosphate buffer pH 7.5)
Antigen in ELISA and Western blots, excellent antigen for early detection of HTLV infections, with minimal specificity problems.
The protein contains the HTLV-1 gp21/gp46 immunodominant fragments, amino acids: 374-400 (gp21) and 190-207 (gp46). The protein is purified by proprietary chromatographic technique.
Background: Human T-cell leukemia virus (HTLV)-1 and -2 are deltaretroviruses that infect a wide range of cells. HTLV-1 has been found primarily in CD4+ and CD8+ T-lymphocytes in vivo, whereas CD8+ T-lymphocytes are thought to be the in vivo reservoir of HTLV-2.
Specificity: Immuno reactive with all sera of HIV-I infected individuals.
BIOZ Product Citations:
Please click the arrow on the right to expand the citation list. Click publication title for the full text.
Toedter et al. (1991) Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infection. AIDS. Res. Hum. Retroviruses. 8:527.
Segal-Eiras et al. (1991) HTLV-I p24 antigen in circulating immune complexes associated with acute Tlymphoblastic leukemia. Haematologica. 76:441.
Stransky et al. (1991) Ultrastructural localization of HTLV-I gag proteins p19 and p24 by single and double immunogold labeling. J. Histochem. Cytochem. 39:185.
Ando et al. (1990) p24 protein of a human T-lymphotropic virus type-I (HTLV-I) producing cell line (TCL-Kan) reacts with some normal pregnant women's sera. Nippon. Sanka. Fujinka. Gakkai. Zasshi. 42:1251.
Ziegler et al. (1989) Immunohistochemical localization of HTLV-I p19- and p24-related antigens in synovial joints of patients with rheumatoid arthritis. Am. J. Pathol. 135:1.
Grimaldi et al. (1988) HTLV-I-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-I p24 antibody. Ann. Neurol. 24:727.