Human T-cell Leukemia Virus Type-1, core protein p24
recombinant, E. coli
For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Purity: > 95 % (SDS-PAGE, RP-HPLC)
Form: liquid (Supplied in 10 mM NaPO4 pH 6.0, 1 mM DTT and 1 mM EDTA)
Antigen in ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.
The protein contains the full-length HTLV-1 major core protein p24. The protein is purified by proprietary chromatographic technique.
Background: Human T-cell leukemia virus (HTLV)-1 and -2 are deltaretroviruses that infect a wide range of cells. HTLV-1 has been found primarily in CD4+ and CD8+ T-lymphocytes in vivo, whereas CD8+ T-lymphocytes are thought to be the in vivo reservoir of HTLV-2.
Specificity: Immuno reactive with all sera of HIV-I infected individuals.
Toedter et al. (1991) Development of a monoclonal antibody-based p24 capsid antigen detection assay for HTLV-I, HTLV-II, and STLV-I infection. AIDS. Res. Hum. Retroviruses. 8:527.
Segal-Eiras et al. (1991) HTLV-I p24 antigen in circulating immune complexes associated with acute Tlymphoblastic leukemia. Haematologica. 76:441.
Stransky et al. (1991) Ultrastructural localization of HTLV-I gag proteins p19 and p24 by single and double immunogold labeling. J. Histochem. Cytochem. 39:185.
Ando et al. (1990) p24 protein of a human T-lymphotropic virus type-I (HTLV-I) producing cell line (TCL-Kan) reacts with some normal pregnant women's sera. Nippon. Sanka. Fujinka. Gakkai. Zasshi. 42:1251.
Ziegler et al. (1989) Immunohistochemical localization of HTLV-I p19- and p24-related antigens in synovial joints of patients with rheumatoid arthritis. Am. J. Pathol. 135:1.
Grimaldi et al. (1988) HTLV-I-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-I p24 antibody. Ann. Neurol. 24:727.