Protein Tyrosine Phosphatase 1B
human, recombinant, E. coli
| Cat. No. | Amount | Price (EUR) | Buy / Note |
|---|---|---|---|
| PR-931 | 20 μg | 286,30 | Add to Basket/Quote Add to Notepad |
For general laboratory use.
Shipping: shipped on dry ice
Storage Conditions: store at -80 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Molecular Weight: 37.3 kDa
Accession number: NP_002818
Purity: > 90 % (SDS-PAGE)
Form: liquid (Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM EDTA, 1 mM DTT and 2 mM beta-Mercaptoethanol)
Activity: 1 nmol of PTP 1B will hydrolyze 37 nmol of pNPP per minute at 30°C.
Description:
PTP 1B is the prototype nontransmembrane protein tyrosine phosphatase. It is a ubiquitous protein that was originally identified in human placenta. This highly active enzyme is well suited for the study of tyrosine phosphatase kinetics and substrate specificity, as well as for the screening of inhibitors.
BIOZ Product Citations:
Selected References:
Montalibet et al. (2004) Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B. Biochem. Pharmacol. 68:1807.
Puius et al. (1997) Identification of a second aryl phosphatebinding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc. Natl. Acad. Sci. USA. 94:13420.
Liu et al. (1996) Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130 (Cas). J. Biol. Chem. 271:31290.
Powered by Bioz
