Cdc25A

For general laboratory use.

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 68 kDa

Accession number: M81933

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 20 mM Tris-HcL pH 8.0, 100 mM NaCl, 1 mM EDTA and 1 mM DTT)

Activity: 1 nmol of Cdc25A will hydrolyze 10 nmol of pNPP per minute at 37°C at pH 8.0.

Description:
The dual specific Cdc25A (Cell division cycle) phosphatase regulates cell cycle progression, has oncogenic and anti-apoptotic activity, and is overexpressed in many human tumors. The protein does not have tags.

Assay buffer: 50 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mM EDTA.

BIOZ Product Citations:

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Selected References:
Fauman et al. (1998) Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell 93:617.
Gottlin et al. (1996) Kinetic analysis of the catalytic domain of human cdc25B. J. Biol. Chem. 271:27445.