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Protein Tyrosine Phosphatase 1B

human, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-931 20 μg 218,50 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 37.3 kDa

Accession number: NP_002818

Accession number: NP_002818

Purity: > 95 % (SDS-PAGE)

Form: liquid (Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM EDTA, 1 mM DTT and 2 mM beta-Mercaptoethanol)

pH: 7.4

Activity: 1 nmol of PTP 1B will hydrolyze 37 nmol of pNPP per minute at 30°C.

PTP 1B is the prototype nontransmembrane protein tyrosine phosphatase. It is a ubiquitous protein that was originally identified in human placenta. This highly active enzyme is well suited for the study of tyrosine phosphatase kinetics and substrate specificity, as well as for the screening of inhibitors.

Selected References:
Montalibet et al. (2004) Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B. Biochem. Pharmacol. 68:1807.
Puius et al. (1997) Identification of a second aryl phosphatebinding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc. Natl. Acad. Sci. USA. 94:13420.
Liu et al. (1996) Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130 (Cas). J. Biol. Chem. 271:31290.