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PTPμ - cytoplasmic region (D1D2)

Protein tyrosine phosphatase

human, recombinant, E. coli

Product Cat. No. Amount Price (EUR) Buy / Note
PTPμ - cytoplasmic region (D1D2) PR-349 20 μg 218,50 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 73 kDa

Accession number: NM_002845

Accession number: NM_002845

Purity: > 95 % (SDS-PAGE)

Form: liquid (Supplied in 10 mM Tris-HCl, 10 mM Bis-Tris-HCl pH 7.0)

pH: 7.0

Activity: 1 nmol of PTPμ will hydrolyze 1.2 nmol of pNPP per minute at 37°C at pH 4.8.

Description:
Protein Tyrosin Phosphatase, cytoplasmic region, containing catalytic domain D1 C-terminally linked to the non-catalytic domain D2. PTPmu is an Ig superfamily receptor protein-tyrosine phosphatase which promotes cell-cell adhesion in a homophilic, Ca2+-independent manner and interacts with the cadherin-catenin complex. The intracellular region of PTPμ contains three domains: the juxtamembrane (JM, aa 765-923) and two phosphatase domains (D1 and D2). Only the D1 domain is catalitically active.

Selected References:
Gebbink et al. (1993) Cell-cell adhesion mediated by a receptor-like protein tyrosine phosphatase. J. Biol. Chem. 268:16101.
Brady-Kalnay et al. (1998) Dynamic interaction of PTPmu with multiple cadherins in vivo. J. Cell Biol. 141:187.
Tonks et al. (1992) Protein tyrosine phosphatases: The problems of a growing family. Cold Spring Harbor Symp. Quant. Biol. 57:87.