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PIM1His - active

Proto-oncogene serine/threonine-protein kinase

human, recombinant, E. coli

Product Cat. No. Amount Price (EUR) Buy / Note
PIM1His - active PR-236 20 μg 483,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 37.5 kDa

Accession number: BC020224

Accession number: BC020224

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 50 mM Tris-HCl pH 8.5, 500 mM NaCl and 1 mM DTT)

pH: 8.5

Activity: > 500,000 U/mg (1 Unit is defined as 1 picomole phosphate transferred to synthetic peptide KKRNRTLTV per min at 30 °C)

Human PIM1 plays multiple roles in tumorigenesis. It promotes early transformation, cell proliferation and cell survival. In addition it may play a role in angiogenesis and vasculogenesis as a downstream effector of the VEGF-A/Flk1 pathway. PIM1 expression is correlated with tumor aggressiveness and is a marker for poor prognosis. PIM1 expression can be predictive of tumor outcome following chemotherapy and surgery and has been correlated with the enhanced metastatic potential of the tumor. Suitable for labeling PIM1 substrates. Features a poly-histidine tag to facilitate removal of PIM1 from reaction mixture.

Selected References:
Shah et al. (2008) Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal. Eur. J. Cancer. 44:2144.