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Ran - Q69L

Ras-related nuclear protein, TC4

human, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-213 50 μg 212,18 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 24.0 kDa (216 amino acids)

Accession number: NM_006325

Accession number: NM_006325

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 50 mM KH2PO4/K2HPO4 pH 7.5, 5 mM DTE and 5 mM MgCl2)

Ran (Ras-related nuclear protein, TC4) belongs to the superfamily of GTP binding proteins. It acts in diverse cellular processes such as nuclear transport, mitotic spindle assembly, and post-mitotic nuclear assembly. Ran Q69L is defective in GTP hydrolysis. Useful as a negative control for Ran binding and import studies. Protein preparation is 34% GDP- and 17% GTPloaded, measured by HPLC.

Product Citations:
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.

Selected References:
Dasso (2002) The Ran GTPase: Theme and Variations. Current Biology 12:502.
Palacios et al. (1996) Ran/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus. J. Cell Biol. 133:485.
Clarke et al. (1995) Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase. J. Cell Sci. 108:1217.
Fritz et al. (2009) RNA-Regulated Interaction of Transportin-1 and Exportin-5 with the Double-Stranded RNA-Binding Domain Regulates Nucleocytoplasmic Shuttling of ADAR1. Mol Biol Evol. 29 (6):1487-1497.