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RIN2-RAGST (residues 785-879)

Ras and Rab interactor 2 - Ras-association domain

human, recombinant, E. coli,
Recognized GTPases: TC21, M-Ras

Cat. No. Amount Price (EUR) Buy / Note
PR-397 500 μg 212,18 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Accession number: NM_018993

Accession number: NM_018993

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 25 mM HEPES pH 7.5, 50 mM NaCl, 1 mM EDTA and 50% glycerol)

RIN2, only expressed in neurons, preferentially interacts with the GTP form of Rab5 rather than the GDP form, although it enhances the guanine exchange reaction on Rab5. Moreover, gel filtration and immunoprecipitation analyses suggest that RIN2 could form a tetramer composed of anti-parallel linkage of two parallel dimers. These results suggest that RIN2 may function as an upstream activator and/or downstream effector for Rab5 in the endocytic pathway. Additionally RIN2 interacts with several Ras proteins, it binds the GTP-loaded forms of H-Ras, TC21 and M-Ras.

Selected References:
Saito et al. (2002). A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. J. Biol. Chem. 277:3412.