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GTP Signal Transduction Proteins - GAPs (GTPase Activation Proteins)

G-proteins (heterotrimeric G-proteins and GTPases of the Ras superfamily) have only a low intrinsic GTPase activity. GTPase activating proteins (GAPs) accelerate the GTP hdrolysis reaction by up to 5 orders of magnitude, thus switching „off“ the activated GTPase and terminating the signaling activity. The malignant transformation of cells is often linked to oncogenic mutations of Ras that escape regulation by GAPs.