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Manganese Superoxide Dismutase

human, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-149 500 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 24 kDa

Accession number: NP_000627

Accession number: NP_000627

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 10 mM potassium phosphate buffer pH 7.5, 40 mM NaCl, 1 mM MnCl2 and 0.1 mM DTT)

Activity: > 1.000 units/mg (one unit is defined as the amount of enzyme that will double the rate of autoxidation of 5,6,6a,11b-tetrahydro - 3,9,10-trihydroxybenzo-[c]-fluorene per minute at 37 °C, pH 8.8).

Manganese Superoxide Dismutase (Mn SOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide radicals to molecular oxygen in the mitochondria of eukaryotic cells. It plays a critical role in the detoxification of mitochondrial reactive oxygen species (ROS) constituting a major cellular defense mechanism against agents that induce oxidative stress. The increased expression of MnSOD suppresses the tumorigenicity of human melanoma cells, breast and prostate cancer cells, and glioma cells, suggesting that MnSOD is a tumor suppressor gene in a wide variety of cancers.

Selected References:
Navarro-Antolín et al. (2007) Role of peroxynitrite in endothelial damage mediated by Cyclosporine A. Free Radical Biology and Medicine 42 (3):394-403.
Venkataraman et al. (2005) Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene 24:77.
Greenlund et al. (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14:303.