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native PrPc (globular domain/residues 90-230)His

Prion Protein, cellular form

mouse, recombinant, E. coli

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native PrPc (globular domain/residues 90-230)His PR-913 5 μg 230,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Accession number: NM_011170 / P04925

Accession number: NM_011170 / P04925

Purity: > 95 % (SDS-PAGE)

Form: liquid (Supplied in 10 mM sodium acetate pH 4.5 and 0.02 % sodium azide)

pH: 4.5

N-terminal His-tagged prion protein globular domain (amino acid residues 90-230). The PrPc-like conformation of the protein after refolding procedure was confirmed by high resolution NMR spectroscopy. The native His-tagged PrPc is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as for in vitro/in vivo conversion studies.

Selected References:
Prusiner (1998) Prions. Proc. Natl. Acad. Sci. USA 95:13363.
Pan et al. (1993) Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA 90:10962.
Lee et al. (1998) Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 8:1022.