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native PrPc (full length/residues 23-230)His

Prion Protein, cellular form

mouse, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-910 5 μg 241,40 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Accession number: NM_011170 / P04925

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 10 mM sodium acetate pH 4.5 and 0.02 % sodium azide)

N-terminal His-tagged full-length prion protein (PrPc). The PrPc -like conformation of the protein after refolding procedure was confirmed by high resolution NMR spectroscopy. The native His tagged PrPc is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as for in vitro/in vivo conversion studies.

Selected References:
Prusiner (1998) Prions. Proc. Natl. Acad. Sci. USA 95:13363.
Pan et al. (1993) Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA 90:10962.
Lee et al. (1998) Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 8:1022.