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Immobilized γ-Aminophenyl-m7GTP (C10-spacer)

γ-Aminophenyl-m7GTP (C10-spacer)-Agarose

Cat. No. Amount Price (EUR) Buy / Note
AC-155S 1 ml 223,86 Add to Basket/Quote Add to Notepad
AC-155L 5 ml 895,45 Add to Basket/Quote Add to Notepad
Structural formula of Immobilized γ-Aminophenyl-m7GTP (C10-spacer) (γ-Aminophenyl-m7GTP (C10-spacer)-Agarose)
Structural formula of Immobilized γ-Aminophenyl-m7GTP (C10-spacer)

For research use only!

Shipping: shipped at 4 °C

Storage Conditions: store at 4 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Applications:
Suitable for purification of eukaryotic mRNA cap-binding proteins.

Degree of substitution: 5 μmol - 7 μmol m7GTP/ml gel

Storage buffer: 20% Ethanol

Product Citations:
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.

Selected References:
Coots et al. (2017) m6A Facilitates eIF4F-Independent mRNA Translation. Mol. Cell. doi:10.1016.
Hou et al. (2017) PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication Viruses 9(9):262.
Theodosakis et al. (2017) p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis. J. Invest. Dermatol. 137(10):2187.
Arimoto-Matsuzaki et al. (2016) TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat. Commun. 7:10252.
Cinti et al. (2016) HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex mBio 7 (2):e00329-16.
Timpano et al. (2016) Analysis of Cap-binding Proteins in Human Cells Exposed to Physiological Oxygen Conditions. J. Vis. Exp. doi:10.3791.
Wahba et al. (2016) Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells. Cancer Res. 76 (10):3078.
Hatakeyama et al. (2014) A Novel Functional Site in the PB2 Subunit of Influenza A Virus Essential for Acetyl-CoA Interaction, RNA Polymerase Activity, and Viral Replication. J. of Biol. Chem. 289:24980.
Igreja et al. (2014) 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation Nat. Commun. 5:4790.
Morino et al. (1996) Crystallization and preliminary X-ray diffraction study of recombinant human eukaryotic initiation factor-4E. J. Biochem. (Tokyo) 119 (2):224.
Webb et al. (1984) Purification of the messenger RNA cap-binding protein using a new affinity medium. Biochemistry 17,23 (2):177.