Since the initial discovery of prenylated fungal proteins, many more proteins have been demonstrated to contain a prenyl modification. Today it's well-known, that protein prenylation affects up to 2% of the proteins in the mammalian proteome.
The proteins listed below are RabGGTase substrates and corresponding proteins.
A geranylgeranyl moiety is attached to one or two C-terminal cysteines of Rab proteins with a hypervariable C-terminal domain. RabGGTase does not recognize its substrate directly, but exerts its function in concert with Rab Escort Protein (REP).
Please note that deletion mutants with truncated C-terminus are not recognized by the protein geranylgeranyltransferase and will thus not be prenylated.