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Ras-associated, small GTP-binding protein

human, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-195 50 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 58 kDa

Accession number: AAH66904

Accession number: AAH66904

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 25 mM HEPES pH 7.2, 40 mM NaCl and 5 mM mercaptoethanol)

pH: 8.0

Activity: 100 pmol of protein can bind > 80 pmol of GDP.

N-terminal tagged Rab34 is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The small GTPase Rab 34 is restricted to cell surface membrane ruffles and lysosmes. It regulates the spatial distribution of lysosomes and is required for formation of macropinosomes. The GST-Tag facilitates the protein`s application in typical GST pull-down assays.

Selected References:
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071.
Yamaguchi et al. (2002) A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Proc. Natl. Acad. Sci. USA. 99:14536.