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Ras-associated, small GTP-binding protein

mouse, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-191 50 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Accession number: NP_033025

Accession number: NP_033025

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM mercaptoethanol)

pH: 8.0

Activity: 100 pmol of protein can bind > 80 pmol of GDP.

Rab23 is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. Rab 23 is expressed at high levels in brain and locolized to plasma membrane and endosomes. It regulates ciliary and sonic hedgehog signalling pathways and is involved in embryogenesis.

Selected References:
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071.
Yamaguchi et al. (2002) A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Proc. Natl. Acad. Sci. USA. 99:14536.