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Ras-associated, small GTP-binding protein

mouse, recombinant, E. coli

Product Cat. No. Amount Price (EUR) Buy / Note
Rab18AGST-His PR-188 50 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Accession number: NP_035355

Accession number: NP_035355

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM mercaptoethanol)

pH: 8.0

Activity: 100 pmol of protein can bind > 80 pmol of GDP.

Rab18A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. Rab18A is localized in dense apical tubules (kidney) and basolateral membrane (intestine) as well as lipid droplets in ER and neuroendocrine secretory granules. The enzyme is involved in the formation of lipid droplets form ER. Furthermore it is a negative regulator of neuroendocrine secretion. The GST-Tag facilitates the protein`s application in typical GST pull-down assays.

Selected References:
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071.
Yamaguchi et al. (2002) A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Proc. Natl. Acad. Sci. USA. 99:14536.