Member of Ras oncogene family
human, recombinant, E. coli
| Cat. No. | Amount | Price (EUR) | Buy / Note |
|---|---|---|---|
| PR-109 | 50 μg | 271,40 | Add to Basket/Quote Add to Notepad |
For general laboratory use.
Shipping: shipped on dry ice
Storage Conditions: store at -80 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Molecular Weight: 23.6 kDa
Accession number: AF498939
Purity: > 90 % (SDS-PAGE)
Form: liquid (Supplied in 40 mM TRIS pH 7.2, 1 mM MgCl2, 40 mM NaCl, 20 μM GDP, 5 mM DTT)
Activity: 100 pmol of protein can bind > 80 pmol of GDP.
Description:
Rab6A is a small GTPase that belongs to the Ras superfamily. It mediates intra-Golgi vesicular trafficking and is geranylgeranylated on both C-terminal cysteines.
Amino Acid Sequence: MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST
QDRSREDMID IKLEKPQEQP VSEGGCSC
BIOZ Product Citations:
Selected References:
Feldmann et al. (1995) Behaviour of the small GTP-binding protein rab6 in the liver of normal rats and rats presenting an acute inflammatory reaction. Biol. Cell 83:121.
Beranger et al. (1994) The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization. Mol. Cell. Biol. 14:744.
Chamberlain et al. (2004) The p85alpha Subunit of Phosphatidylinositol 3'-Kinase Binds to and Stimulates the GTPase Activity of Rab Proteins. J. Biol. Chem. 279 (47):48607.
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