Rab7

Ras-associated, small GTP-binding protein

dog, recombinant, E. coli

Cat. No. Amount Price (EUR) Buy / Note
PR-108 50 μg 207,00 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Weight: 23.5 kDa

Accession number: NM_001003316

Accession number: NM_001003316

Purity: > 90 % (SDS-PAGE)

Form: liquid (Supplied in 25 mM HEPES pH 7.2, 40 mM NaCl, 5 mM DTT, 2 mM MgCl2 and 10 μM GDP)

pH: 7.2

Activity: GTPγS binding: >750 mmol/mol.

Description:
Rab7 is a 23.5 kDa small GTPase localized in late endosomes. Rab7 regulates late endocytic membrane traffic between endosomes and lysosomes. The protein contains a C-terminal CXC motif for post-translational geranylgeranylation.

Selected References:
Vitelli et al. (1997) Role of the small GTPase RAB7 in the late endocytic pathway. J. Biol. Chem. 272:4391.
Bottger et al. (1996) Rab4 and Rab7 define distinct nonoverlapping endosomal compartments. J. Biol. Chem. 271:29191.
Chavrier et al. (1990) Localization of low-molecular-weight GTP binding-proteins to exocytic and endocytic compartments. Cell 62:317.
Watanabe et al. (2008) Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds. J. Biol. Chem. 283 (15):9571-9579.