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Manumycin A

Streptomyces parvulus

FTase Inhibitor

Cat. No. Amount Price (EUR) Buy / Note
INH-012 1 mg 194,35 Add to Basket/Quote Add to Notepad
Structural formula of Manumycin A (Streptomyces parvulus)
Structural formula of Manumycin A

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Formula: C31H38N2O7

Molecular Weight: 550.7 g/mol

CAS#: 52665-74-4

Purity: > 96 % (HPLC)

Form: yellow to brown solid

Solubility: soluble in DMSO or methanol

Manumycin A is a potent cell-permeable inhibitor of Ras farnesyltransferase (IC50 30 nM). It does not affect geranylgeranyltransferase (IC50 =180 μM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase and blocks insulin-induced MAP kinase activation in rat cardiac myocytes.

Selected References:
Gibbs et al. (1994) Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77 (2):175