For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Molecular Formula: C31H38N2O7
Molecular Weight: 550.7 g/mol
Purity: > 96 % (HPLC)
Form: yellow to brown solid
Solubility: soluble in DMSO or methanol
Manumycin A is a potent cell-permeable inhibitor of Ras farnesyltransferase (IC50 30 nM). It does not affect geranylgeranyltransferase (IC50 =180 μM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase and blocks insulin-induced MAP kinase activation in rat cardiac myocytes.
Gibbs et al. (1994) Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77 (2):175