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FTase Inhibitor

Protein farnesyltransferase inhibitor

Cat. No. Amount Price (EUR) Buy / Note
INH-009 1 mg 216,20 Add to Basket/Quote Add to Notepad

Structural formula of B581

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Formula: C22H38N4O3S2

Molecular Weight: 470.7 g/mol

CAS#: 149759-96-6

Purity: > 96 % (HPLC)

Form: white powder

B581 is a cell-permeable farnesyltransferase inhibitor IC50 =21 nM, 30-fold selective over geranylgeranyltransferase.

Selected References:
Cox et al. (1994) The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J.Biol.Chem. 269:19203