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Src substrate peptide


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PE-211 1 mg 183,60 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Formula: KVEKIGEGTYGVVYK

Molecular Weight: 1670 g/mol

Purity: 90 - 95 % (HPLC)

Form: lyophilized (reconstitution in ddH2O)

The synthetic peptide KVEKIGEGTYGVVYK can be used as a substrate for Src kinase in in vitro kinase assays. It is phosphorylated by Src with a Km of 101 μM.
Src (p60c-src) is a 60 kDa cytoplasmic tyrosine kinase with functions in the regulation of cell division, cell-matrix adhesion, and cell-cellcell adhesion. Src family tyrosine kinases participate in signal transduction of different classes of membrane receptors, including receptor tyrosine kinases and G-protein coupeled receptors.

Selected References:
Cheng et al. (1992) A synthetic peptide derived from p34CDC2 is a specific and efficient substrate of src family tyrosine kinases. J. Biol. Chem. 267:9248.
Erpel et al. (1995) Src family protein tyrosine kinases and cellular signal transduction pathways. Curr. Opin. Cell. Biol. 7:176.
Markova et al. (2003) Identification of protein-tyrosine phosphatases associating with the PDGF-receptor. Biochemistry 42:2691.
Honda et al. (2002) Platelet-activating factor receptor. J. Biochem. 131:773.