For in vitro use only!
Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Molecular Formula: PKTPKKAKKL
Molecular Weight: 1138 g/mol
Purity: 90 - 95 % (HPLC)
Form: lyophilized (reconstitution in ddH2O)
The synthetic peptide PKTPKKAKKL can be used as a substrate for Cdk5 (cyclin-dependent kinase 5) for in vitro kinase assays. It is phosphorylated by Cdk5 with a Km of 6 μM.
Cdk5 is predominantly active in the nervous system and plays an essential role in neuronal development. Aberrant Cdk5 activity has been reported in neurodegenerative disorders such as Alzheimer's disease, amylotrophic lateral sclerosis and Parkinsons's disease.
Beaudette et al. (1993) Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. J. Biol. Chem. 268:20825.
Fischer et al. (1993) CDK5 in the adult non-demented brain. Curr. Drug Targets CNS Neurol. Disord. 2:375.
Shelton et al. (2004) Cyclin dependent kinase-5 in neurodegeneration. J. Neurochem. 88:1313.