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Cdk5 substrate peptide


Cat. No. Amount Price (EUR) Buy / Note
PE-204 1 mg 183,60 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C
avoid freeze/thaw cycles

Shelf Life: 12 months

Molecular Formula: PKTPKKAKKL

Molecular Weight: 1138 g/mol

Purity: 90 - 95 % (HPLC)

Form: lyophilised (reconstitution in ddH2O)

The synthetic peptide PKTPKKAKKL can be used as a substrate for Cdk5 (cyclin-dependent kinase 5) for in vitro kinase assays. It is phosphorylated by Cdk5 with a Km of 6 μM.
Cdk5 is predominantly active in the nervous system and plays an essential role in neuronal development. Aberrant Cdk5 activity has been reported in neurodegenerative disorders such as Alzheimer's disease, amylotrophic lateral sclerosis and Parkinsons's disease.

Selected References:
Beaudette et al. (1993) Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. J. Biol. Chem. 268:20825.
Fischer et al. (1993) CDK5 in the adult non-demented brain. Curr. Drug Targets CNS Neurol. Disord. 2:375.
Shelton et al. (2004) Cyclin dependent kinase-5 in neurodegeneration. J. Neurochem. 88:1313.