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Staurosporine

Antibiotic AM 2282

Protein Kinase Inhibitor

Cat. No. Amount Price (EUR) Buy / Note
INH-005 50 μg 74,75 Add to Basket/Quote Add to Notepad

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C

Shelf Life: 12 months

Molecular Formula: C28H26N4O3

Molecular Weight: 466.5 g/mol

CAS#: 62996-74-1

Purity: ≥ 98 %

Form: lyophilized

Solubility: 20 mg/ml soluble in DMSO, slightly soluble in Ethanol and Methanol. Insoluble in water.

Description:
Staurosporine is a potent cell permeable inhibitor of many kinases including Protein Kinase C, Protein Kinase A, CaM kinase, myosin light chain kinase, and PI3K (IC50 = 9 μM).
The biological effects of Staurosporine include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression. It inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation.
Staurosporine induces apoptosis in human malignant glioma cell lines and arrests normal cells at the G1 checkpoint.

Source:
Streptomyces staurosporeus

Selected References:
Walker et al. (2000) Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine. Mol. Cell. 6:909.
Wan et al. (2002) PTEN augments staurosporine-induced apoptosis n PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway. Cell Death Differ. 9:414.
Lee et al. (2000) Divergent effects of protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I (GF109203X) on bone resorption. Biochem. Pharmacol. 60:923.
Takano (1994) Staurosporine inhibits STA2-induced platelet aggregation by inhibition of myosin light-chain phosphorylation in rabbit washed platelets. Ann. N. Y. Acad. Sci. 714:315.
Matsumoto et al. (1989) Staurosporine a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells. Biochem. Biophys. Res. Comm. 158:105.