Protein Kinase Inhibitor
For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Molecular Formula: C15H10O8
Molecular Weight: 318.24 g/mol
Purity: ≥ 95 %
Solubility: 10 mg/ml soluble in DMSO, 1 mg/ml soluble in Ethanol. Insoluble in Acetic Acid.
Myricetin is a flavonoid that differs from quercetin only by the addition of a hydroxyl at the 5’-OH of the phenyl moiety. It shows cytotoxic activity against several human leukemic cell lines in vitro.
It strongly inhibits yeast a-glucosidase, glyoxalase I in vitro, cow's milk xanthine oxidase, and PI3-Kinase (IC50 = 1.8 μM).
Myricetin both modulates Na+/K+-ATPase-induced vasodilatation acting as a functional inhibitor of Na+/K+-ATPase activity and activates protein kinases, including PKC, to induce contraction. These effects appear to be related to the activation of PGH2-TXA2 receptors on vascular smooth muscle by the TXA2 released from endothelium.
Walker et al. (2000) Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine. Mol. Cell. 6:909.
Jimenez et al. (2002) Involvement of protein kinase C and Na+/K+ - ATPase in the contractile response induced by myricetin in rat isolated aorta. Planta Med. 68:133.
Dimas et al. (2000) Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro. Pharmacol Res. 42:475.
Ong et al. (1997) Biological effects of myricetin. Gen. Pharmacol. 29:121.