For research use only!
Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Shelf Life: 12 months after date of delivery
Molecular Formula: C50H54N4O9
Molecular Weight: 854.99 g/mol
Purity: ≥ 90 % (HPLC)
Form: amorphous solid to sticky semisolid
Solubility: DCM, DMF, DMSO, THF
Conversion of azide group into DBCO group
Post-synthetic modification of azido-containing peptides
DBCO-PEG4-DBCO is a reagent for converting of azido-modified peptides or biopolymers into DBCO-modified peptides or biopolymers. When applied in stoichiometric amount DBCO-PEG4-DBCO can serve as a homofunctional azide-to-azide crosslinker for covalently linking azido-modified peptides or biopolymers via a stable triazole moiety. Once a peptide or biopolymer is DBCO-labeled, it can be reacted with an azide-labeled molecule to produce a stable conjugate. The DBCO group reacts with an azide to produce a stable triazole, which is also referred to as the Cu(I)-free or strain-promoted click reaction.
Procedure for Conversion Reaction for Small Molecules
Problem: large amount of crosslinked product if formed
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