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Alkyne-containing Bifunctional Reagents

Alkyne-containing reagents can be used for the introduction of

  • a functional group to Azide-labeled molecules via a Cu(I)-catalyzed Azide-Alkyne Click Chemistry reaction (CuAAC)
  • an Alkyne group to various targets e.g. via NHS Ester- or Maleimide-based chemistry


Table 1: Available Alkyne-containing Bifunctional Reagents

Reactive GroupAlkyne
NHS esterPropargyl-NHS ester
Acetylene-PEG4-NHS ester
Acid (-COOH)Acetylene-PEG4-Acid
Amine (-NH2)Acetylene-PEG4-Amine