For in vitro use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
protect from light
Shelf Life: 12 months after date of delivery
Molecular Weight: 1079 Da confirmed by MALDI-MS, peptide provides 2 positive and one negative charge for complex formation. 3 trifluoroacetate residues may be present resulting in an apparent MW of 1.6 kDa.
Purity: ≥ 95 % (HPLC)
Cys-[3-Abu-minimaurocalcine(1-9)] is a highly potent CPP isolated from Tunesian scorpion Scorpio Maurus palmatus. The full-length maurocalcine is a 33-mer basic peptide cross-linked by three disulfide bridges. Many analogues have been derived by internal cysteine replacement by 2-aminobutyric acid (Abu) and by sequence truncation. The fragment 1-9 matches the hydrophobic face of maurocalcine. Protonation of histidine residue renders the cell-penetration pH-sensitive. The fragment can thus be used to specifically target cancer cells because they grow in more acidic environment. Maurocalcine potently and reversibly modifies channel gating behavior of the type 1 ryanodine receptor. It binds to disialoganglioside GD3 at cell surface.
Cys-functionalized Minimaurocalcine allows covalent coupling of thiol reactive compounds e.g.
Perform calculation, complex formation and cargo transduction according to detailed protocols given in the general manual.
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 Dewkar et al. (2012) Synthesis of novel peptide linkers: simultaneous cyclization and labeling. Organic Lett. 11 (20):4708.
Tansi et al. (2019) New generation CPPs show distinct selectivity for cancer and noncancer cells J. Cell. Biochem. 120 (4):6528.