Uridine 5'-triphosphate, Trisodium salt trihydrate
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H15N2O15P3 (free acid)
Molecular Weight: 484.14 g/mol (free acid)
Purity: ≥ 90 % (HPLC)
Spectroscopic Properties: λmax 262 nm, ε 9.8 L mmol-1 cm-1 (Tris-HCl pH 7.0)
Activation of purinergic receptors[1,2,3,4]
Cardioprotection against hypoxic damage
Enzyme kinetic parameters
Phosphorylation of EGF-receptor vie purinergic receptors
Stimulation of neurogenesis and dopaminergic neurons
Enterovirus 71 3D RNA polymerase
Ligand for purinergic receptors:
Quality Control Specifications: in vitro transcription (T7 RNA polymerase): visible RNA fragments after 5 min incubation, DNases, RNases, Nicking Activity: not detectable, Proteases: not detectable
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.
 Raqeeb et al. (2011) Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium 49:240.
 Golan et al. (2011) Extracellular nucleotide derivatives protect cardiomyocytes against hypoxic stress. Biochemical Pharmacology 81:1219.
 Boucher et al. (2011) Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. American Journal Pathology 178:1092.
 Sugihara et al. (2011) Dual signaling pathway of arterial constriction by extracellular uridine-5-triphosphate in the rat. J. Pharmacological Sciences (Japan) 115:293.
 Ma et al. (2011) Molecular cloning and analysis of the UDP-glucose pyrophosphorylase in Streptococcus equi subsp. Zooepidemicus. Molecular Biology Reports 38:2751.
 Delic et al. (2011) Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Puronergic Signalling 6:417.
 Jiang et al. (2011) Biochemical characterization of enterovirus 71 3D RNA polymerase. Biochim. Biophys. Acta, Gene Regulatory Mechanisms 1809:211.
 Pendergast et al. (2001) Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. 11 (2):157.
 Shaver et al. (1997) 4-substituted uridine 5'-triphosphates as agonists of the P2Y2 purinergic receptor. Nucleosides and Nucleotides 16 (7):1099.
 Kim et al. (2002) Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4 and P2Y11 but not P2Y6 receptors. J. Med. Chem. 45:208.
 Nguyen et al. (1995) Cloning, expression, and chromosomal localization of human uridine nucleotide receptors. J. Biol. Chem. 270 (52):30845.