8-Oxo-2'-deoxyadenosine-5'-triphosphate, Sodium salt
8-Hydroxy-2'-deoxyadenosine-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H16N5O13P3 (free acid)
Molecular Weight: 507.18 g/mol (free acid)
Exact Mass: 507.00 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 100 mM - 110 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 267 nm, ε 13.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Malvezzi et al. (2015) Quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors. Anal. Biochem. 478:1.
Kamiya (2010) Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases. Mutat. Res. 703 (1):32.
McLennan (2006) The Nudix hydrolase superfamily. Cell. Mol. Life Sci. 63 (2):123.
Hori et al. (2005) In vivo mutagenicities of damaged nucleotides produced by nitric oxide and ionizing radiation. Biol. Pharm. Bull. 28 (3):520.
Fujikawa et al. (1999) The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J. Biol. Chem. 274 (26):18201.