8-Oxo-2'-deoxyguanosine-5'-monophosphate, Sodium salt
8-Hydroxy-2'-deoxyguanosine-5'-monophosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H14N5O8P (free acid)
Molecular Weight: 363.22 g/mol (free acid)
Exact Mass: 363.06 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 245 nm, ε 12.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Crystal structure in complex with human MTH1
Hydrolysis by MutT
Marker of oxidative stress
Parameters of pyrophposphohydrotase reaction of MutT
Solution structure of complex with MutT
Tight binding to MutT
 Svensson et al. (2011) Crystal structure of human MTH1 and 8-oxo-dGMP product complex. FEBS Letters 585:2617.
 Nakamura et al. (2010) Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J. Biological Chem. 285:444.
 Sangsuwan et al. (2008) The nucleotide pool, a target for low-dose y-ray induced oxidative stress. Radiation Research 170:776.
 Xia et al. (2005) Transient state kinetic studies of the MutT-catalyzed nucleoside triphosphate pyrophosphohydrolase reaction. Biochemistry 44:15334.
 Massiah et al. (2004) Solution structure, mutagenesis, and NH-exchange studies of the MutT enzyme Mg2+-8-oxo-GMP complex. J. Molecular Structure 700 (1-3):247.
 Saraswat et al. (2004) Mutational, NMR, and NH-exchange studies of the tight and selective binding of 8-oxo-GMP by the MutT pyrophosphohydrolase. Biochemistry 43:3404.
Kaminsky et al. (2007) The c-Myc Target Gene Rcl (C6orf108) Encodes a Noval Enzyme, Deoxynucleoside 5'-monophosphate N-Glycosidase. J. Biol. Chem. 282 (11): 8150.