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8-Oxo-dGMP

8-Hydroxy-dGMP

8-Oxo-2'-deoxyguanosine-5'-monophosphate, Sodium salt

8-Hydroxy-2'-deoxyguanosine-5'-monophosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-1153S 50 μl (10 mM) 117,35 Add to Basket/Quote Add to Notepad
NU-1153L 5 x 50 μl (10 mM) 343,76 Add to Basket/Quote Add to Notepad
Structural formula of 8-Oxo-dGMP (8-Hydroxy-dGMP, 8-Oxo-2'-deoxyguanosine-5'-monophosphate, Sodium salt)
Structural formula of 8-Oxo-dGMP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C10H14N5O8P (free acid)

Molecular Weight: 363.22 g/mol (free acid)

Exact Mass: 363.06 g/mol (free acid)

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 245 nm, ε 12.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Crystal structure in complex with human MTH1[1]
Hydrolysis by MutT[2]
Marker of oxidative stress[3]
Parameters of pyrophposphohydrotase reaction of MutT[4]
Solution structure of complex with MutT[5]

Specific Ligands:

Tight binding to MutT[6]

Selected References:
[1] Svensson et al. (2011) Crystal structure of human MTH1 and 8-oxo-dGMP product complex. FEBS Letters 585:2617.
[2] Nakamura et al. (2010) Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base. J. Biological Chem. 285:444.
[3] Sangsuwan et al. (2008) The nucleotide pool, a target for low-dose y-ray induced oxidative stress. Radiation Research 170:776.
[4] Xia et al. (2005) Transient state kinetic studies of the MutT-catalyzed nucleoside triphosphate pyrophosphohydrolase reaction. Biochemistry 44:15334.
[5] Massiah et al. (2004) Solution structure, mutagenesis, and NH-exchange studies of the MutT enzyme Mg2+-8-oxo-GMP complex. J. Molecular Structure 700 (1-3):247.
[6] Saraswat et al. (2004) Mutational, NMR, and NH-exchange studies of the tight and selective binding of 8-oxo-GMP by the MutT pyrophosphohydrolase. Biochemistry 43:3404.
Kaminsky et al. (2007) The c-Myc Target Gene Rcl (C6orf108) Encodes a Noval Enzyme, Deoxynucleoside 5'-monophosphate N-Glycosidase. J. Biol. Chem. 282 (11): 8150.

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