7-Methyl-guanosine-5'-diphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C11H17N5O11P2 (free acid)
Molecular Weight: 457.23 g/mol (free acid)
Exact Mass: 457.04 g/mol (free acid)
CAS#: 117723-13-4 (free acid), 104809-16-7 (sodium salt)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 258/280 nm, ε 9.8/8.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Inhibition of cap-dependent translation
Inhibition of mitotic division
Inhibition of decapping
 Allam et al. (2010) Initiation factor eIF2- independent mode of c-src mRNA translation occurs via an internal ribosome entry site. J. Biol. Chem. 285:5713.
 Oulhen et al. (2007) After fertilization of sea urchin eggs, eIF4G is post-translationally modified and associated with the cap-binding protein eIF4E. J. Cell Science 120:425.
 Parrish et al. (2007) Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression. Proc. Natl. Acad. Sci. (USA) 104:2139.
Shen et al. (2001) Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods. Chem Pharm Bull 49 (10):1299.
Carberry et al. (1989) A spectroscopic study of the binding of m7GTP and m7GpppG to human protein synthesis initiation factor 4E. Biochemistry 28 (20):8078.
Beemon et al. (1977) In vitro translation yields a possible Rous sarcoma virus src gene product. Proc Natl Acad Sci U S A. 74 (8):3302.