2'-O-Methylcytidine-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H18N3O14P3 (free acid)
Molecular Weight: 497.18 g/mol (free acid)
Exact Mass: 497.00 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 100 mM - 110 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 271 nm, ε 9.1 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Lauridsen et al. (2012) Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: towards the evolution of versatile aptamers. Chembiochem. 13 (1):19.
Xiao et al. (2012) Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection. ACS Nano 6 (1):696.
Keefe et al. (2008) SELEX with modified nucleotides. Curr. Opin. Chem. Biol. 12 (4):448.
Burmeister et al. (2006) 2'-Deoxy purine, 2'-O-methyl pyrimidine (dRmY) aptamers as candidate therapeutics. Oligonucleotides 16 (4):337.
Dutartre et al. (2006) General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues. Antimicrob. Agents Chemother. 50 (12):4161.
Burmeister et al. (2005) Direct in vitro selection of a 2'-O-methyl aptamer to VEGF. Chem. Biol. 12 (1):25.