» Sign in / Register

Mant-ITPγS

2'/3'-O-(N-Methyl-anthraniloyl)-inosine-5'-(γ-thio)-triphosphate, Triethylammonium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-981 150 μl (10 mM) 930,00 Add to Basket/Quote Add to Notepad
Structural formula of Mant-ITPγS (2'/3'-O-(N-Methyl-anthraniloyl)-inosine-5'-(γ-thio)-triphosphate, Triethylammonium salt)
Structural formula of Mant-ITPγS

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 6 months after date of delivery

Molecular Formula: C18H22N5O14P3S (free acid)

Molecular Weight: 657.37 g/mol (free acid)

Purity: ≥ 90 % (HPLC)

Form: colorless to slightly yellow solution in water

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 279/355 nm, ε 20.5/5.7 L mmol-1 cm-1 (Tris-HCl pH 7.5), λexc 355 nm, λem 448 nm

Selected References:
Seifert et al. (2012) Inhibitors of membranous adenylyl cyclases. Trends Pharmacol. Sci. 33 (2):64.
Hübner et al. (2011) Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes. J. Naunyn Schmiedebergs Arch. Pharmacol. 383 (4):573.
Erdorf et al. (2011) Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. J. Naunyn Schmiedebergs Arch. Pharmacol. 383 (4):357.
Goettle et al. (2009) Characterization of Mouse Heart Adenylyl Cyclase. J. Pharmacol. Exp. Ther. 329 (3):1156.
Goettle et al. (2007) Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides. Molecular Pharmacology 72 (3):526.
Gille et al. (2004) Differential Inhibition of Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by Purine and Pyrimidine Nucleotides. J. Biol. Chem. 279 (19):19955.