Mant-ITPγS
For research use only.
Please centrifuge briefly before opening (volume ≤2 ml).
Shipping: shipped on dry ice
Storage Conditions: store at -20 °C
Shelf Life: 6 months after date of delivery
Molecular Formula: C18H22N5O14P3S (free acid)
Molecular Weight: 657.38 g/mol (free acid)
Exact Mass: 657.01 g/mol (free acid)
Purity: ≥ 90 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 279/355 nm, ε 20.5/5.7 L mmol-1 cm-1 (Tris-HCl pH 7.5), λexc 355 nm, λem 448 nm
Selected References:
Seifert et al. (2012) Inhibitors of membranous adenylyl cyclases. Trends Pharmacol. Sci. 33 (2):64.
Hübner et al. (2011) Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes. J. Naunyn Schmiedebergs Arch. Pharmacol. 383 (4):573.
Erdorf et al. (2011) Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes. J. Naunyn Schmiedebergs Arch. Pharmacol. 383 (4):357.
Goettle et al. (2009) Characterization of Mouse Heart Adenylyl Cyclase. J. Pharmacol. Exp. Ther. 329 (3):1156.
Goettle et al. (2007) Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides. Molecular Pharmacology 72 (3):526.
Gille et al. (2004) Differential Inhibition of Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by Purine and Pyrimidine Nucleotides. J. Biol. Chem. 279 (19):19955.
At this point, external content from bioz.com is embedded. When it loads, data (e.g. your IP address) is transmitted to the provider.
Scientific citations for Jena Bioscience nu-981
4 scientific citations and 0 citation images found by Bioz.
-
Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice
PLoS ONE, 2013-07-01 · PMID:23840883
.. was purchased from Biolog (Bremen, Germany).GTPγS (guanosine 5′-[γ-thio]triphosphate) was purchased from Biolog (Bremen, Germany)..
MANT-ITPγS (2′(3′)- O -( N -methylanthraniloyl)-inosine 5′-[γ-thio]triphosphate) was obtained fromJena Bioscience (Jena, Germany).. Neutral alumina (N Super 1) was purchased from MP Biomedicals (Eschwege, Germany).Neutral alumina (N .. -
Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes.
Naunyn-Schmiedeberg's archives of pharmacology, 2011-09-01 · PMID:21484439
Abstract: Membranous adenylyl cyclases play a major role in G-protein-coupled receptor signalling and regulate various cellular responses, such as cardiac contraction. Cardiac apoptosis and development of cardiac dysfunction is prevented in mice lacking AC 5, a predominant isoform in the heart. In the search for a potent and selective AC 5 inhibitor, we recently identified 2'(3')-methylanthraniloyl-inosine-5'-triphosphate(MANT-ITP) as the most potent AC 5 inhibitor with a K ( i ) of 13 nM
-
Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes.
Naunyn-Schmiedeberg's archives of pharmacology, 2011-06-20 · PMID:21279330
Abstract: Polycystic kidney disease (PKD) is the most common life-threatening genetic disorder with bilateral cysts caused by increased level of cyclic adenosine 3',5'-monophosphate (cAMP). Since adenylyl cyclases (ACs) catalyze cAMP formation, pharmacological characterization of renal AC isoforms is essential. Therefore, we analyzed differences in activation, inhibition, and regulation of AC isoforms in rabbit cortex and medulla membranes
